For most post-menopausal women whose cancers are hormone receptor-positive, most doctors recommend taking an AI at some point during adjuvant therapy. Right now, standard treatment is to take these drugs for about 5 years, or to alternate with tamoxifen for a total of at least 5 years, or to take in sequence with tamoxifen for at least 3 years. Studies are now being done to see if taking an AI for more than 5 years would be more helpful. Tamoxifen is an option for some women who cannot take an AI. Taking tamoxifen for 10 years is considered more effective than taking it for 5 years, but you and your doctor will decide the best schedule of treatment for you.
FEMARA is only approved for use in postmenopausal women. You should not take FEMARA if you are premenopausal. Your doctor should discuss the need for adequate birth control if you have the potential to become pregnant (for example, if you are not sure of your postmenopausal status or recently became postmenopausal, or if you are perimenopausal). You should not take FEMARA if you are pregnant, as it may cause harm to an unborn child. You should also discuss with your doctor what to do if you are nursing a child. You and your doctor should decide whether to discontinue nursing or to discontinue the drug.
Anastrozole has been tested for reducing estrogens, including estradiol, in men.  Excess estradiol in men can cause benign prostatic hyperplasia , gynecomastia , and symptoms of hypogonadism . It can also contribute to increased risk of stroke, heart attack, chronic inflammation, prostate enlargement and prostate cancer.  Some athletes and body builders use anastrozole as part of their steroid cycle to reduce and prevent symptoms of excess estrogen-- gynecomastia , emotional lability and water retention.  Study data suggest dosages of mg to 1 mg a day reduce serum estradiol by approximately 50% in men, which differs in postmenopausal women.