Anavar is highly ranked among the safest steroids because it is very minimally toxic to the liver. In fact, previously it was prescribed for liver damage patients as well as those with alcoholic hepatitis. Studies reveal that a daily dose of Oxandrolone taken in a period of 6 weeks had a negligible impact on the liver and instead improved protein production and hepatic homeostasis. It was also found that Oxandrolone does not cause hepatomegaly which in layman’s terms is swelling of the liver. Unlike other anabolic-androgenic steroids, it has minimal effect on blood pressure and both LDL and HDL cholesterol levels. It should be noted, however, that when used in too high a dosage and for too long, it may cause a strain on the liver by preventing it from breaking down active ingredients. Mild loss of appetite, fatigue and anxiety has also been reported with connection to its use.