We are always on top of the latest news regarding steroids. Whether it`s steroids in sports like baseball, football, bodybuilding, boxing, or the olympics-we cover it! Our news blog is updated daily with fresh content that involves steroid use around the world. is a great resource for learning about a variety of topics regarding performance enhancing drugs like dianabol, anadrol, deca-durabolin, winstrol-v, and sustanon.
Our website provides information about anabolic steroids strictly for educational reasons only. If you are interested in learning about the latest headlines involving the use of steroids and HGH (human growth hormone) , than you have come to the right place. It`s important to always consult your physician before taking any drugs and that includes legal steroids. Please understand and make clear that does not approve or condone illegal use of anabolic steroids without a doctors prescription. Be sure to understand the laws in the country you reside when you plan to buy steroids . will not be responsible for anyone who has misused an anabolic steroid, or other legal steroids described on this website. Must be 18 years old to visit and view the contents of
Please consult with your physician before you buy steroids or buy anabolic steroids .
In addition to their characteristic hydroxylase activities, some steroidogenic CYP enzymes also catalyse lyase reactions. Specifically, the CYP11A (cytochrome P450 cholesterol side chain cleavage) and CYP17 (cytochrome P450 17α-hydroxylase/C17,20-lyase) enzymes can each catalyse cleavage of the C․C bond weakened by the hydroxylation reactions. CYP11A acts in the IMM to catalyse the rate-limiting reaction in steroid synthesis: the conversion of cholesterol to pregnenolone. This crucial CYP enzyme hydroxylates two adjacent carbons (C20 and C22) in the D-ring side chain of cholesterol, facilitating cleavage between C20 and C22 to leave the Δ 5 21 carbon steroid, pregnenolone ( Miller 2008 ). Similarly, CYP17 introduces a hydroxyl group at position C17 of either pregnenolone or progesterone, as a result of which the weakened C17–C20 bond breaks to generate either DHEA or androstenedione, respectively ( Miller 2008 ) (see Figure ). Other members of the CYP enzyme family simply catalyse introduction of oxygen to generate hydroxyl groups at specific carbon positions (see Table ). The hydroxylations catalysed by CYP21 (21-hydroxylase) and CYP11B1 (11β-hydroxylase) are pivotal in the formation of corticosteroids by the adrenal cortex ( Miller 2008 ). The hydroxyl group generated at position C18 by CYP11B2 (aldosterone synthase) undergoes rapid oxidation to form an aldehyde group ( Curnow et al 1991 ), hence giving rise to the name ‘aldosterone’ (see Figure ). Finally, CYP19 (aromatase) is the most complex member of the steroidogenic CYP enzyme family, catalysing a series of reactions that convert C19 androgens (androstenedione and testosterone) to their C18 oestrogen metabolites (oestrone and oestradiol, respectively). In this reaction sequence, the C19 methyl group is lost and the ketone at position C3 is reduced to a hydroxyl group ( Miller 2008 ). This liberates electrons which are invested in the A-ring of the steroid to generate the aromatic phenol ring, the hallmark of oestrogens (see Figure ) and a prerequisite for activation of the oestrogen receptor.
Read Our CrazyBulk Bulking Stack Reviews From Crazy Bulk Customers P Paul R. Verified Buyer I am really glad that I got this Bulking Stack as it has made such a huge difference to my workouts and has really bulked me up. Took about a week to fully kick in but when it did my strength increased and allowed me to train harder for longer periods of time. I gained approx. 20lbs of muscle mass at the end of the 8 week period and my strength increased in all aspects of my training. Am definitely going to continue using the Bulking Stack only because it worked so well..