Steroid tablets asthma side effects

As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes. [28]

This confusing situation happens often, even when the rescue and maintenance inhalers are of different color. The root problem is lack of standardization among inhalers, with unclear labeling to distinguish between rescue and maintenance inhalers. A contributing cause is lack of proper education for both the caregivers and their patients . All too often proper instructions were not given when the drug was first prescribed. And even when they are provided, patients sometimes don't really understand, or they forget. Either way, having similar inhalers for different purposes is an invitation to error. (This was less likely to be a problem when the drug was studied by the drug companies; see YELLOW BOX above, under 'DPI Type 2'.) The problem is compounded when patients are on multiple inhalers, eg, Proventil for rescue, Advair and Spiriva for maintenance. That's 3 separate devices with two different purposes -- easy for the patient to get confused. (Pills and capsules come in many colors and sizes, but they are all swallowed the same way.) What's needed is a universal delivery device for all inhalers, with perhaps just two colors: red for rescue drugs and green for maintenance drugs. Anyone with clinical interest in the inhaler problems discussed above (Errors 1 & 2) should definitely read Problems With Inhaler Use: A Call for Improved Clinician and Patient Education , by James B. Fink and Bruck K. Rubin (Respiratory Care, Sept 2005, Vol 50, No. 10, pages 1360-75). 3. Not checking some objective measurement of the patient's air flow obstruction. Every patient should have a breathing test to ascertain the degree of impairment caused by the asthma. The most frequently performed test is 'spirometry', which takes just a few minutes and requires the patient to exhale forcefully thru a testing device (shown below).
A patient performing the spirometry test


Graphs from a normal spirometry test; left panel, graph of flow vs. volume; right panel, graph of time vs. volume.

Dear sir,
Thanks a lot. I am really inspired with your efforts to remove quite a lots of misconceptions about Homeopathy in general public. Many Leading Homeo drs are least interested in educating people about this. Many times i have asked my doctor ( one of the leading homeo dr in my city) and he says that it is out of jealousy people are spreading this propaganda. But my question is what is your effort in preventing this spread of false propaganda. Anyway i am really happy that, though you are always a busy person, but when approached- very mild, scientific tempered and matured person. May god give you more and more strength to spread homeopathy in a scientific spirit.

Steroid tablets asthma side effects

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