One of the potential complications of steroid shots in the nose is development of a depression in the area of the injection. Just as steroids can work to dissolve mature scar tissue, they can also cause normal soft tissue to dissolve away. This process where soft tissue shrinks down is also known as atrophy. This can occur if the steroid solution gets into the surrounding skin and fat and causes the soft tissues to atrophy. If this does occur, we normally wait several weeks and simply observe the tissues. In most cases, your body will rebound on its own and restore some, if not all, of the lost soft tissue volume. Fortunately, unwanted soft tissue atrophy following a steroid injection is not very common, especially if your rhinoplasty specialist takes a more conservative approach with choice of steroid concentration and volume.
Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian .  Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats .  It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide.  Valproic acid has also been used for migraine prophylaxis and bipolar disorder.