Ecdysteroid agonist

The ecdysteroid-binding pocket is located in the ligand binding domain of the EcR subunit , but EcR must be dimerised with a USP (or with an RXR) for high-affinity ligand binding to occur. In such circumstances, the binding of an agonist ligand triggers a conformational change in the C-terminal part of the EcR ligand-binding domain that leads to transcriptional activation of genes under ECRE control. [7] There is also a ligand-binding pocket in the corresponding domain of USP. Its natural ligand remains uncertain, and USPs appear to be locked permanently in an inactive conformation . [8]

Ecdysteroid agonist

ecdysteroid agonist

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