Biotech pharma steroids

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In January 2014, Novartis announced plans to cut 500 jobs from its pharmaceuticals division. [51] In February 2014, Novartis announced that it has acquired CoStim Pharmaceuticals. [52] In May 2014, Novartis bought the rights to market Ophthotech 's Fovista (an anti- PDGF aptamer , also being investigated for use in combination with anti- VEGF treatments) outside the United States for up to $1 billion. [53] Novartis will acquire exclusive rights to market the eye drug outside of America whilst retaining US marketing rights. The company agreed to pay Ophthotech $200 million upfront, and $130 million in milestone payments relating to Phase III trials. [53] Ophthotech is also eligible to receive up to $300 million dependent upon future marketing approval milestones outside of America and up to $400 million relating to sales milestones. [54] In September 2014, Ophthotech received its first $50 million phase III trial milestone payment from Novartis. [55] In April 2014, Novartis announced that it would acquire GlaxoSmithKline 's cancer drug business for $16 billion as well as selling its vaccines business to GlaxoSmithKline for $ billion. [56] In August 2014 Genetic Engineering & Biotechnology News reported that Novartis had acquired a 15% stake in Gamida Cell for $35 million, with the option to purchase the whole company for approximately $165 million. [57] In October 2014, Novartis announced its intention to sell its influenza vaccine business (inclusive of its development pipeline), subject to regulatory approval, to CSL for $275 million. [58]

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Calcium Indicators are small molecules that can chelate calcium ions. All these molecules are based on an EGTA homologue called BAPTA (with exception of coelenterazines), with high selectivity for calcium (Ca) ions versus magnesium (Mg) ions. This group of indicators includes fura-2, indo-1, fluo-3, BTC, Rhod-2, etc. These dyes are generally used with the chelator carboxyl groups masked as acetoxymethyl esters, in order to render the molecule lipophilic and to allow easy entrance into the cell. Once the indicator is in the cell, cellular esterases will free the carboxyl and the indicator will be able to bind calcium.

Biotech pharma steroids

biotech pharma steroids

Calcium Indicators are small molecules that can chelate calcium ions. All these molecules are based on an EGTA homologue called BAPTA (with exception of coelenterazines), with high selectivity for calcium (Ca) ions versus magnesium (Mg) ions. This group of indicators includes fura-2, indo-1, fluo-3, BTC, Rhod-2, etc. These dyes are generally used with the chelator carboxyl groups masked as acetoxymethyl esters, in order to render the molecule lipophilic and to allow easy entrance into the cell. Once the indicator is in the cell, cellular esterases will free the carboxyl and the indicator will be able to bind calcium.

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