The first sulfonamide and the first systemically active antibacterial drug, Prontosil , was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany,    for which Domagk received the 1939 Nobel Prize in Physiology or Medicine.  Sulfanilamide, the active drug of Prontosil, was not patentable as it had already been in use in the dye industry for some years.  Prontosil had a relatively broad effect against Gram-positive cocci , but not against enterobacteria . Research was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials.  
This is one area where the Anabolic diet has a big advantage over the competition. When you’re on the high carb diet, your body is already saturated with carbohydrates so it’s difficult to manipulate the diet so the body will respond well to your carb loading attempt before the contest. What often happens is that you’ll get off your high carb diet for 3 days at the beginning of the week before a competition and go low carb for 72 hours. Then you’ll carb up to try and hit the contest right. The problem is, you really don’t know how your body’s going to react.
A good general guideline for carb intake would be to consume 5-8 grams of carbs per pound of body weight. Eight grams would be the high end for those who are performing a lot of exercise during the week and are completely depleting their stores, while five would be more moderate for those who are exercising but aren't performing as much volume. Do note that you will likely see some weight gain immediately after a carbohydrate loading period however this will most likely be water weight and will go away after returning to the normal diet protocol.